Description
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH2) is a synthetic pentapeptide and third-generation Growth Hormone Secretagogue (GHS) developed to selectively stimulate growth hormone release with a high degree of receptor specificity. Its primary research value lies in its clean selectivity profile — unlike earlier GHS compounds, Ipamorelin does not produce significant concurrent increases in cortisol, prolactin, or adrenocorticotropic hormone (ACTH), making it a precise tool for isolating pituitary GH release pathways in laboratory models.
Mechanism of Action
- GHS-R1a Agonism: Ipamorelin binds selectively to the ghrelin receptor (GHS-R1a) in the anterior pituitary and hypothalamus, triggering a robust, pulsatile release of endogenous Growth Hormone.
- Selectivity Profile: Research demonstrates Ipamorelin’s high selectivity — it stimulates GH secretion without the off-target activation of cortisol or ACTH axes observed with first- and second-generation secretagogues such as GHRP-2 and GHRP-6.
- Hypothalamic Synergy: Studies indicate Ipamorelin acts synergistically with endogenous Growth Hormone-Releasing Hormone (GHRH), amplifying pulsatile GH output when both pathways are active simultaneously — a key area of neuroendocrine axis research.
Research Applications
- Neuroendocrine Axis Studies: Ipamorelin is used to investigate the hypothalamic-pituitary axis and the regulation of pulsatile GH secretion patterns.
- Receptor Binding Research: Its high GHS-R1a affinity and selectivity make it a valuable reference compound for receptor pharmacology and agonist binding studies.
- Comparative Secretagogue Research: Frequently used alongside CJC-1295 and GHRP-class peptides to study differential receptor activation and downstream signaling cascades in pituitary cell models.
Quality Assurance
- Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Molecular Formula: C₃₈H₄₉N₉O₅
- Molecular Weight: 711.86 g/mol
- Purity: >99% Verified by HPLC/MS
- Form: Sterile White Lyophilized Powder
- Storage: Store at -20°C for long-term stability. Stable at 4°C for short-term use once reconstituted.
FOR RESEARCH USE ONLY:
This product is sold strictly as a chemical reference standard for in-vitro laboratory research purposes only. It is not intended for human or animal consumption, injection, or administration of any kind. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. Bodily introduction into humans or animals is strictly prohibited. For use by qualified research professionals only.
